Treatment of SLE

First line treatment:

Hydroxychloroquine

Mild SLE: low dose steroid

Aggressive SLE: moderate dose steroid

Severe SLE: high dose steroid, combine with either cyclophosphamide, mycophenolate mofetil, or azathioprine

Hydroxychloroquine: continue indefinitely

Switch from cyclophosphamide to mycophenolate mofetil, or azathioprine in 3 to 6 mo